WebMar 29, 2024 · Temozolomide protects against the progression of glioblastoma via SOX4 downregulation by inhibiting the LINC00470-mediated transcription factor EGR2. Wenyang Li, ... Overexpression of LINC00470 or SOX4 partially abolished the suppressive effect of temozolomide and conspicuously elevated tumor volume and weight in nude mice in the … WebMay 27, 2024 · Besides, overexpression of Klotho could significantly enhance autophagy and AMPK and ERK1/2 activities in vivo and in vitro, which also could be abolished by …
Klotho protects against diabetic kidney disease via AMPK- and …
WebApr 15, 2024 · The Klotho gene (also known as α-Klotho) is located on chromosome 13q12 and it was first identified as an anti-aging factor 33. It is expressed in the kidney and even less in the pancreatic ... WebOverexpression also protects against the development of Alzheimer’s disease-like synaptic change and cognitive impairment (Dubal et al. 2015). In humans, a polymorphism that … for sale china spring tx
Suppression of Aging in Mice by the Hormone Klotho Science
WebMar 1, 2024 · KLOTHO is a type of β-glucuronidase engaged in the development and progression of reproductive diseases with anti-aging and antioxidant properties . Decreased KLOTHO expression was found in women with DOR , and overexpression of KLOTHO was related to higher blastocyst formation frequency in porcine cell lines . Our bioinformatics … WebNov 29, 2024 · These data suggest that klotho overexpression protects against kidney aging along with suppression of TGF-β1 signaling pathways. NEW & NOTEWORTHY Klotho is considered as an antiaging protein, and its overexpression may be a candidate therapy for protection against kidney damage with advanced aging. WebKlotho is a novel biomarker involved in aging. In this study, we evaluated the protective effects of klotho overexpressed adipose-derived stem cells (ADSCs) against ultraviolet … digitalis purpurea snow thimble